As the information collection device of the current domestic down-hole gathers less information and with low precision, the down-hole monitoring system with multi-parameter is designed in this paper. The system can be used on electric submersible pump to achieve two-way pressure, two-way temperature, leakage current, and vibration signals in real-time acquisition. Filtering the collected data, and using curve fitting algorithm on the pressure sensor for temperature compensation to ensure the accuracy of the data. Test results show that the system can withstand the harsh down-hole environments encountered in an oil well. Plus, the gathered data has high precision and timeliness. Accordingly, it reaches the expected target.