The Correlation between MSCT for Lung Volume and Airway Measurements and Pulmonary Function Test


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Objective To study the correlation between the airway dimensions from third to five generation of bronchi, and pulmonary function test(PFT) results in patients with chronic obstructive pulmonary disease(COPD) by using inspiratory and expiratory multisection computed tomography(MSCT). Materials and Methods The study included 19 patients with COPD who underwent both inspiratory and expiratory CT. For each patient, airway luminal areas and wall thickness from the third to fifth generations of RB1 and RB10 were measured. Correlations between these parameters and PFT results were evaluated. Results The correlation coefficients between airway luminal at expiratory CT and PFT results were higher than those for inspiratory CT, and improved as the airway size decreased from the third to the fifth generations. Conclusion Some parameters of airway luminal are significantly correlated with PFT. MSCT can be used to assess the pulmonary function of patients with COPD.



Advanced Materials Research (Volumes 383-390)

Edited by:

Wu Fan




Z. S. Deng et al., "The Correlation between MSCT for Lung Volume and Airway Measurements and Pulmonary Function Test", Advanced Materials Research, Vols. 383-390, pp. 5334-5338, 2012

Online since:

November 2011




[1] Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: updated 2005. NHLBI/ WHOworkshop and report. Global Initiative for Chronic Obstructive Lung Disease Web site. http: /www. goldcopd. com/. Updated 2005. Accessed September 1, (2007).


[2] Hogg JC, Macklem PT, Thurlbeck WM. Site and nature of airways obstruction in chronic obstructive lung disease. N Engl J Med. 1968; 278: 1355-1360.


[3] Yanai M, Sekizawa K, Ohrui T, Sasaki H, Takishima T. Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J Appl Physiol. 1992; 72: 1016-1023.

[4] Rydberg J, Buckwalter KA, Caldemeyer KS, et al. Multisection CT: scanning techniques and clinical applications. Radiographics, 2000; 20(3): 1787-1806.


[5] Nakano Y, Muro S, Sakai H, et a1. Computed tomographic measurements of airway dimensions and emphysema in smokers: correlation with lung function. Am J Respir Crit Care Med, 2000; 162(3 Pt 1): 1102-1108.


[6] Hasegawa M, Nasuhara Y, 0nodera Y, et a1. Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2006; 173(12): 1305-1315.


[7] Ferretti GR. Vining DJ, Knoplioch J, Coulomb M. Tracheobronchial tree three-dimensional spiral CT with bronchoscopic perspective. J Comput Assist Tomogr, 1996; 20(5): 777-781.


[8] Wood SA, Zerhouni EA, Hoford JD, et al. Measurement of Three-dimensional Lung Tree Structures by Using Computed Tomography. J Appl Physiol, 1995; 79(5): 1687-1697.

[9] Kalender WA, Fichte H, Bautz W, et al. Semiautomatic evaluation procedures for quantitative CT of the lung. Computer Assist Tomography, 1991; 15(2): 248-255.