Synthesis of Anti-Cancer Targeted Therapies Drug Tivozanib

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Tivozanib was synthesized through the cyclization, chlorinated, condensation reaction with 2-amino-4,5-dimethoxy acetophenone as the starting material. All synthetic compounds were analyzed by FT-IR, 1H-NMR, MS and HPLC. The purity of tivozanib was more than 98.5%. Synthetic routs and methods of tivozanib are feasible to industrial production owing to the cheap raw materials, mild reaction conditions, stable technology and high yield.

Info:

Periodical:

Advanced Materials Research (Volumes 396-398)

Edited by:

Yanxuan Wen and Fuhou Lei

Pages:

1490-1492

Citation:

M. X. Liu et al., "Synthesis of Anti-Cancer Targeted Therapies Drug Tivozanib", Advanced Materials Research, Vols. 396-398, pp. 1490-1492, 2012

Online since:

November 2011

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$38.00

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