Synthesis of Anti-Cancer Targeted Therapies Drug Tivozanib
Tivozanib was synthesized through the cyclization, chlorinated, condensation reaction with 2-amino-4,5-dimethoxy acetophenone as the starting material. All synthetic compounds were analyzed by FT-IR, 1H-NMR, MS and HPLC. The purity of tivozanib was more than 98.5%. Synthetic routs and methods of tivozanib are feasible to industrial production owing to the cheap raw materials, mild reaction conditions, stable technology and high yield.
Yanxuan Wen and Fuhou Lei
M. X. Liu et al., "Synthesis of Anti-Cancer Targeted Therapies Drug Tivozanib", Advanced Materials Research, Vols. 396-398, pp. 1490-1492, 2012