The technologies of ion exchange resin for ultra pure hydrogen peroxide production are more and more focused. The aim of this research was to determine suitable parameters for effective removal of Na+ impurities from aqueous hydrogen peroxide solution to produce ultra pure hydrogen peroxide. Dynamic experiments for the different operation conditions, i.e., initial concentration, flow rate, ratio of height to diameter were carried out. The concentrations of Na+ of the effluents from the ion exchange resin column were determined by ICPS-7510.The breakthrough curves of Na+ were measured and analyzed. The results shown that Na+ could be reduced effectively from the experimental aqueous hydrogen peroxide solution with the fitting conditions of ion exchange resin column, which provided the basis for determining of the suitable operating conditions of ion exchange column of a pilot plant.