Antibacterial Efficiency and Cellular Toxicity of PET-Based Hollow Fibers Containing Silver Particles

Abstract:

Article Preview

This work focuses on antibacterial efficacy and cellular toxicity of PET-based hollow fiber with silver particles incorporated (Ag/PET hollow fiber), which was synthesized by differential pressure method. Escherichia coli (E. coli) were used to investigate the antibacterial capability of Ag/PET hollow fiber with antibacterial kinetics experiments. The antibacterial results demonstrated that Ag/PET hollow fiber had an excellent antibacterial property against E. coli and the efficacy was dependent on several aspects including fiber length, weight and silver content. The cytotoxicity of Ag/PET hollow fibers on WI-38 cells was assessed using Methyl Thiazolyl Tetrazolium (MTT) assay, and the results showed no significant toxicity to WI-38 cells. SEM images of WI-38 cells treated by Ag/PET hollow fibers showed that cells morphology was unaltered in the presence of Ag/PET hollow fiber. However, abnormal size, shrinkage and rounded appearance of cells at higher dose suggested slight toxicity of Ag/PET hollow fiber. Combining the antibacterial and cytotoxic results, it was found that there was a certain concentration of silver ions which can achieve a minimization of cytotoxicity and a maximization of antibacterial efficacy.

Info:

Periodical:

Edited by:

Jianzhong Shao and Qinguo Fan

Pages:

279-283

Citation:

L. Lin et al., "Antibacterial Efficiency and Cellular Toxicity of PET-Based Hollow Fibers Containing Silver Particles", Advanced Materials Research, Vol. 441, pp. 279-283, 2012

Online since:

January 2012

Export:

Price:

$41.00

[1] L Lin, WZ Gong, SJ Chen, JW Ma, DM Su, SY Wang, Structural characterization and antibacterial study of silver fiber, Paper presented at the 2008 International Symposium on Fiber-Based Scaffolds for Tissue Engineering, Donghua University, Shanghai, December 8-9, (2008).

[2] L Lin, WZ Gong, SJ Chen, JW Ma, DM Su, SY Wang, Structure and antibacterial analysis of silver fiber, Paper presented at the Fiber Society 2009 Spring Conference, Donghua University, Shanghai, May 27-29, (2009).

[3] L Lin, WZ Gong, SY Wang, Hollow PET fibers containing silver particles as antibacterial materials, J. Text. I. 102 (2011) 419-423.

DOI: https://doi.org/10.1080/00405000.2010.486185

[4] QL Feng, J Wu, GQ Chen, FZ Cui, TN Kim, JO Kim, A mechanistic study of the antibacterial effect of silver ion on Escherichia coli and Staphylococcus aureus, J. Biomed. Mater. Res. 52 (2000) 662.

DOI: https://doi.org/10.1002/1097-4636(20001215)52:4<662::aid-jbm10>3.0.co;2-3

[5] VKM Poon, A Burd., In vitro cytotoxity of silver: implication for clinical wound care, Burns. 30 (2004) 140-147.

DOI: https://doi.org/10.1016/j.burns.2003.09.030

[6] S Arora, J Jain, JM Rajwade, KM Paknikar, Cellular responses induced by silver nanoparticles: In vitro studies, Toxicol. Lett. 179 (2008) 93-100.

DOI: https://doi.org/10.1016/j.toxlet.2008.04.009

[7] KF Soto, C A arrasco, TG Powell, LE Murr, KM Garza, Biological effects of nanoparticulate materials, Mater. Sci. Eng: C. 26 (2006) 1421-1427.

[8] KD Rosenman, A Moss, S Kon, Argyria: clinical implications of exposure to silver nitrate and silver oxide, J. Occup. Environ. Med. 21 (1979) 430-435.

[9] ME Innes, N Umraw, JS Fish, M Gomez, RC Cartotto, The use of silver coated dressings on donor site wounds: a prospective, controlled matched pair study, Burns. 27 (2001) 621-627.

DOI: https://doi.org/10.1016/s0305-4179(01)00015-8

[10] L Lin, X Wang, XQ Li, SY Wang, Preparation and characterization of antibacterial PET-based hollow fibers containing silver particles, Mater. Lett. 65 (2011) 1375-1377.

DOI: https://doi.org/10.1016/j.matlet.2011.02.006

[11] HJ Klasen, Historical review of the use of silver in the treatment of burns I. Early uses, Burns. 26 (2000) 117-130.

DOI: https://doi.org/10.1016/s0305-4179(99)00108-4