Fabrication of Poly(L-Latic Acid) Scaffolds with Wool Keratin for Osteoblast Cultivation

Abstract:

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As a natural protein, wool keratin was used to improve the cell affinity of poly(L-lactic acid) (PLLA). Small keratin particles were prepared from keratin solution by the spray-drying process. Keratin particles were blended with PLLA/1,4 dioxane solution and paraffin micro-spheres which were used as progens. After the mixture was molded and dried, the paraffin micro-spheres were removed by cyclohexane. PLLA/keratin scaffolds with controlled pore size and well interconnectivity were fabricated. Keratin releasing rate was detected by Fourier transform infrared (FTIR) after the scaffold was immersed into PBS up to 4 weeks. The surface chemical structure was examined by X-ray photoelectron spectroscope (XPS). The results suggested that the keratin could be held into the scaffold which was expected to improve the interactions between osteoblasts and the polymeric scaffolds.

Info:

Periodical:

Advanced Materials Research (Volumes 47-50)

Edited by:

Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam

Pages:

845-848

DOI:

10.4028/www.scientific.net/AMR.47-50.845

Citation:

J. S. Li et al., "Fabrication of Poly(L-Latic Acid) Scaffolds with Wool Keratin for Osteoblast Cultivation", Advanced Materials Research, Vols. 47-50, pp. 845-848, 2008

Online since:

June 2008

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Price:

$35.00

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