Hierarchical Porous Hollow Microsphere for Drug Release
Hierarchical porous titanate nanotube hollow microspheres were synthesized through a template-hydrothermal method. First, SiO2@TiO2 core-shell structure was synthesized, and then titanate nanotube hollow sphere was prepared via a simple hydrothermal method. The dimension of the cavity could be simply tuned by controlling the size of SiO2 spheres. These hollow microspheres exhibited a unique porous structure, in which the nanotube hollow microsphere had a two-fold storage system including the cavity of the hollow sphere and the nanotube capability. Further, the microsphere demonstrated an improved controlled releasing performance that the cavity was capable of giving a fast releasing, while the channel of the nanotube showed a slow releasing property. This facile template-hydrothermal method could be a generally strategy to prepare hollow nanostructures.
Wenzhe Chen, Qiang Li, Yonglu Chen, Pinqiang Dai and Zhengyi Jiang
H. Liu et al., "Hierarchical Porous Hollow Microsphere for Drug Release", Advanced Materials Research, Vols. 476-478, pp. 1379-1382, 2012