Effect of Nano Biphasic Calcium Phosphate Bioceramics on Periodontal Regeneration in the Treatment of Alveolar Defects


Article Preview

The aim of the present study is to investigate the efficacy of nanobiphasic calcium phosphate (nanoBCP) bioceramic in the treatment of periodontal osseous defects. Alveolar bone defects were surgically created bilaterally at the buccal aspects of four second premolars in two beagle dogs. After root leveling, nanoBCP was randomly filled in one defect and nothing was put into the contralateral defect as negative controls. Bioglass was randomly filled in one of left defect as positive controls and nothing was put into the contralateral defect as negative controls. Dogs were killed at the 12th week. Histological observations were processed through a light microscopy. The results reveal that a great amount of functional periodontal fissures formed in the defects in the nanoBCP groups and bioglass groups while no new bone formed in the control groups at all. In this study, nanoBCP has proven to work well as a biocompatible and bioactive material to promote periodontal regeneration effectively.



Edited by:

Guohui Yang




L. L. Wang et al., "Effect of Nano Biphasic Calcium Phosphate Bioceramics on Periodontal Regeneration in the Treatment of Alveolar Defects", Advanced Materials Research, Vol. 486, pp. 422-425, 2012

Online since:

March 2012




[1] Mellonig, James T. DDS, MS,Bone Allografts in Periodontal Therapy. Clin Orthop Relat R. 1996;324: 116-125.

[2] Gestrelius S, Lyngstadaas SP, Hammarström L,Emdogain–periodontal regeneration based on biomimicry. Clin Oral Invest. 2000;4: 120–125.

DOI: https://doi.org/10.1007/s007840050127

[3] Sculean A, Donos N, Brecx M, Karring T, Reich E,Healing of fenestration-type defects following treatment with guided tissue regeneration or enamel matrix proteins An experimental study in monkeys. Clin Oral Invest. 2000;4: 50–56.

DOI: https://doi.org/10.1007/s007840050113

[4] Sun WB, Chu CL, Wang J, Zhao HT,Comparison of periodontal ligament cells responses to dense and nanophase hydroxyapatite. J Mater Sci: Mater Med. 2007;18: 677–683.

DOI: https://doi.org/10.1007/s10856-006-0019-8

[5] Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC,the efficacy of bone replacement grafts in the treatment of periodontal osseous defects. Ann periodontol. 2003;8: 227-65.

DOI: https://doi.org/10.1902/annals.2003.8.1.227

[6] Daculsi G, Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute. Biomaterials. 1998;19: 1473—1478.

DOI: https://doi.org/10.1016/s0142-9612(98)00061-1

[7] Ellinger RF, Nery EB, Lynch KL, Histological assessment of periodontal osseous defects following implantation of hydroxyapatite and biphasic calcium phosphate ceramics: a case report. J Period Res Dent. 1986;6: 22-33.

[8] Shi H, Ma J, Zhao N, Chen YX, Liao YM,Periodontal regeneration in experimentally-induced alveolar bone dehiscence by an improved porous biphasic calcium phosphate ceramic in beagle dogs. J Mater Sci: Mater Med. 2008;19: 3515–3524.

DOI: https://doi.org/10.1007/s10856-008-3524-0

[9] Caton JG, Greenstein GG, Factors related to periodontal regeneration. Periodontol 2000. 1993;1: 9–15.

[10] Ducheyne P, Qiu Q, Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. Biomaterials. 1999;20: 2287-2303.

DOI: https://doi.org/10.1016/s0142-9612(99)00181-7

[11] Sculean A, Barbe G, Chiantella GC, Arweiler NB, Berakdar M, Brecx M (2002).

[12] Keles GC, Cetinkaya BO, Albayrak D, Koprulu H, Acikgoz G (2006) Comparison of platelet pellet and bioactive glass in periodontal regenerative therapy. Acta Odont Scand 64: 327–333.

DOI: https://doi.org/10.1080/00016350600758651