Effect of Apatite Wollastonite Glass Ceramic Addition on Brushite Bone Cement Containing Chitosan
Apatite wollastonite glass ceramic (AW-GC) (34.2% SiO2, 44.9% CaO, 16.3%P2O5, 4.6% MgO, 0.5% CaF2) was added into a brushite bone cement, which composed of β-tricalcium phosphate (β-Ca3(PO4)2, β-TCP) and monocalcium phosphate monohydrate (Ca (H2PO4)2H2O, MCPM) in powder phases. Cement was prepared using a 3 β-TCP:2 MCPM in weight ratio. To evaluate the effect of AW-GC on the mechanical strength and degradability of brushite bone cement, the powder phases and 1 wt.% of chitosan dissolved in 5 wt.% of citric acid solution were mixed and soaked in simulated body fluid solution at 37 °C for 1, 3, 5,7 and 14 days, respectively. The compressive strength and setting time of AW-GC added in brushite bone cement were studied and compared with pure brushite cement. The pH values increased with addition of AW-GC. Additionally, the obtained brushite bone cements were characterized by XRD, SEM techniques.
N. Srakaew, S. T. Rattanachan, "Effect of Apatite Wollastonite Glass Ceramic Addition on Brushite Bone Cement Containing Chitosan", Advanced Materials Research, Vol. 506, pp. 106-109, 2012