The Synthesis of Novel Chiral Ferrocenyl Aziridino Alcohol Ligands with Two Stereogenic Carbons and Structural Characteristics
L-threonine (2S,3S) was obtained from easily available L-threonine (2S,3R) after four steps,then seven chiral ligands 9a-9g were prepared by the esterification,condensation,reductive alkylation,cyclization,then reduction with treatment with RMgX.All seven kinds of novel compounds were characterized by 1HNMR,13CNMR,IR and HRMS.Compound 9a was further characterized by X-ray diffraction.The X-ray structure analysis revealed that an intermolecular hydrogen bond is present.
Reza Iranpour, Ji Zhao, Aijie Wang, Fenglin Yang and Xinyong Li
Q. Wang et al., "The Synthesis of Novel Chiral Ferrocenyl Aziridino Alcohol Ligands with Two Stereogenic Carbons and Structural Characteristics", Advanced Materials Research, Vols. 518-523, pp. 266-271, 2012