Chinese maifan-stone (CMS) is Chinese traditional mineral medicine, in which there are lots of soluble mineral elements. In this paper static soaping to leach mineral elements and dry or wet gringding maifan-stone simultaneously leaching mineral elements was studied. The result shows that: much more mineral elements were leached from Maifan-stone by the method that wet vibrating mill than by the method that soaking fine Maifan-stone after dry-milling. And the factors influencing on the mineral concentration such as milling time and solid/liquid mass ratio were investigated. Furthermore, the possibility of wet-milling simultaneously to leaching mineral elements from Maifan-stone to industrialization was analyzed, and pointed out that it has good industrialization foreground.