Injectable Surfactant Included-Virgin Coconut Oil with and without Ibuprofen
In the tropical countries, virgin coconut oil (VCO) has been abundantly utilized as traditional medicine and cosmetic, but its major problem is temperature sensitive. This oil changes into some wax-like at cool environment. The purpose of this study is to decrease wax deposition of this oil by investigate the effect of surfactants on the physical properties and drug release characteristic. Ibuprofen (IB), which can soluble in VCO, was used as a model drug. Viscosity, pour point, cloud point and polarized light microscope examinations were conducted to characterize the change of VCO physical properties. In vitro drug release experiment was performed using dialysis method at 50 rpm and 37°C in phosphate buffer pH 7.4. The addition of surfactants in VCO increased the efficiency for measuring the viscosity at lower temperature. Result from viscosity measurement indicated that Solutol® HS15 (ST) was the most suitable for choosing as representative of the surfactants. Both pour point and cloud point could not reduce by ST because the crystals size of VCO with and without ST was not different. There was no difference of viscosity of each formula during the release experiments (37°C), therefore the release rate of drug from VCO containing or without ST was not different. These indicated that the surfactants and ibuprofen affected the physical properties but did not affect the release of this investigated VCO.
Jimmy (C.M.) Kao, Wen-Pei Sung and Ran Chen
S. Anuchatkidjaroen and T. Phaechamud, "Injectable Surfactant Included-Virgin Coconut Oil with and without Ibuprofen", Advanced Materials Research, Vols. 581-582, pp. 108-111, 2012