Synthesis and Characterization of β-Cyclodextrin Microspheres with Temperature and pH Sensibility


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The β-CD/NIPAAm-SA microspheres with temperature and pH sensibility were synthesized with β-cyclodextrin(β-CD), N-isopropylacrylamide(NIPAAm) and succinic anhydride(SA), and their drug-releasing properties were investigated. SEM showed that the β-CD/NIPAAm-SA microspheres had a good sphericity and a grain size of 200-300µm.And the swelling results indicated that the swelling rate was decreased with temperature raising and increased with pH value improving, and the phase transition volume changed suddenly at the temperature of about 27°C and 38°C, and the pH values of about 1.4 and 7.4. It revealed that the β-CD/NIPAAm-SA microspheres had pH and temperature sensibilities.



Edited by:

B. Xu and H.Y. Li




Q. Zhang et al., "Synthesis and Characterization of β-Cyclodextrin Microspheres with Temperature and pH Sensibility", Advanced Materials Research, Vol. 583, pp. 391-394, 2012

Online since:

October 2012




[1] Zhang X Z, Chu C C: Polymer, Vol. 46(2005), p.9664.

[2] Ankareddi I, Brazel C S: Int J Pharm, Vol. 336(2007), p.241.

[3] Pey Y, Chen J, Yang L, et al: J Biomater Sci Polym Ed, Vol. 15(2004), p.585.

[4] Liu S Q, Yong Y Y, Liu X M, Tong Y W: Biomacromolecules, Vol. 4(2003), p.1784.

[5] Xu X D, Wei H, Zhang X-Z, et al: J Biomed Mater Res A, Vol. 81(2007), p.418.

[6] Choi C, Chae S Y, Nah J W: Polymer, Vol. 47(2006), p.4571.

[7] Iemma F, Spizzirri U G, Puoci F, et al: Int J Pharm, Vol. 312(2006), p.151.

[8] Xiaoying Yang, Liting Chen, Bo Huang, et al: Polymer, Vol. 50(2009), p.3556.

[9] Ramkissoon-Ganorkar C, Liu F, Baudys M, Kim SW: J Controlled Release, Vol. 39(1999), p.287.

[10] Wei J-S, Zeng H-B, Liu S-Q, et al: Front Biosci, Vol. 10(2005), p.3058.