PLGA Nanoparticles for Anti Tuberculosis Drug Delivery


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Nanoparticles-based drug delivery systems have considerable potential for the treatment of tuberculosis (TB). A series of PLGA polymers with different molar feed ratios (P2:87/13, P3:83/17, P5:63/37, P6:76/24, P9:53/47) were synthesized by direct melt poly condensation method. The resulting biodegradable polymers were characterized by FTIR and 1H NMR spectroscopy. The preparation of the drug (Pyrazinamide (PZA)) encapsulated PLGA polymers were carried out by double emulsion – solvent evaporation technique. The drug loaded PLGA-NPs were analyzed by UV-visible spectroscopy and scanning electron microscopy. The drug loading efficiency and drug release kinetics varies in the following order: P9>P5>P6>P3>P2. Among the formulations, PP9 showed a uniform as well as sustained drug release. The drug release kinetics has been evaluated by Zero-order, First order, Higuchi and Koresmeyer- Peppas models and the release mechanism has also been investigated



Edited by:

D. Rajan Babu




S. Malathi and S. Balasubramanian, "PLGA Nanoparticles for Anti Tuberculosis Drug Delivery", Advanced Materials Research, Vol. 584, pp. 465-469, 2012

Online since:

October 2012




[1] K. Jamshidi, T. Shimizu, T. Usui, R.C. Eberhart, V. Mooney, Resorbable structured porous materials in the healing process of hard tissue defects. ASAIO Trans. 34 (1988) 755-760.

[2] Y-Y. Hsu, J.D. Gresser, R.R. Stewart, D.J. Trantolo, C.M. Lyons, G.A. Simons, P.R. Gangadharam, D.L. Wise. Mechanisms of Isoniazid release from poly(d, l-lactide-co-glycolide) matrices prepared by dry-mixing and low density polymeric foam methods J. Pharm. Sci. 85 (1996).


[3] S. Malathi.; S. Balasubramanian, Rifampicin–loaded Poly (lactic-co-glycolic) acid microspheres: Synthesis, characterization, delivery and their antimicrobial studies. J. Bionanosci, 5 (2011) 1-6.


[4] R. Pandey, A. Zahoor, S. Sharma. Nanoparticle encapsulated antitubercular drugs as a potential oral drug delivery system against murine tuberculosis. Tuberculosis, 83, (2003), 373-378.


[5] D. Klose, F. Siepmann K. Elkharraz, J. Siepmann, PLGA-based drug delivery systems: importance of the type of drug and device geometry. Int. J. Pharm. 354 (2008) 95-103.