The Preparation and Characteristics of Chitosan-Acetaminophen Drug-Loading Micropheres
CS-ACAP drug-loading microsperes are prepared with using CS and ACAP as the main raw materials by emulsification-crosslinking method. Orthogonal experiment was designed to optimize the preparation process of the CS-ACAP drug-loading microspheres. FT-IR and SEM were applied to characterize the structure and morphology of microspheres. The sustained release effect of CS-ACAP microsphere was measured by sustained release measurement. The results showed that the CS-ACAP drug-loading micropheres were successfully prepared by emulsification-crosslinking method. Obtained microspheres as a perforated sphere, the average particle size of the microspheres was 30μm and the microspheres had a uniformly particle size distribution; the drug-loaded microspheres had good sustained release effect.
H. R. Zhou et al., "The Preparation and Characteristics of Chitosan-Acetaminophen Drug-Loading Micropheres", Advanced Materials Research, Vol. 586, pp. 161-165, 2012