Study on Blood Compatibility of a Disposable Burette Transfusion Apparatus and its Pyrogen Test

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The aim of this study is to evaluate the blood compatibility of disposable burette transfusion apparatus and provide the basis for the clinical safety of medical products. Whole blood clotting time (WBCT), prothrombin time(PT),partial prothrombin time(PTT), hemolytic rate and bacterial endotoxin were measured. The results showed that there was no significant difference between the samples and the negative control on indexes of WBCT, PT and PTT (p>0.05), hemolysis test showed that the hemolysis rate of the sample was 1.38% (less than 5%), which was coincident with the criteria of the medical devices. Endotoxin levels were lower than 0. 5 EU/ml. All of the results above suggested that the disposable burette transfusion apparatus had a good blood compatibility and no pyrogen.

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Periodical:

Edited by:

Liangzhong Jiang

Pages:

367-371

Citation:

Y. Huang et al., "Study on Blood Compatibility of a Disposable Burette Transfusion Apparatus and its Pyrogen Test", Advanced Materials Research, Vol. 590, pp. 367-371, 2012

Online since:

November 2012

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$38.00

[1] Charles JM, David RH, Robert SS. Novel stents for theprevention of pestenosis, [J]. TCM , 1997, 7(7): 245-246.

[2] ISO10993-4: Evaluation of medical devices-part 4: selection of tests for interactions with blood. 2002, 2-10.

[3] Zhao Zhiming, Peng Chenghong, Han Baosan, et al. In vitro blood compatibility of polyacrylamide grafted polypropylene membrane, Journal of Clinical Rehabilitative Tissue Engineering Research, 2010, 14(8): 1517-1520.

[4] Xiang Baozhao, Huo Danqun, Hou Changjun, et al. Study on the heparinized anticoagulant biological materials Modern Medical Equipment and Application, 2002, 14(4): 25-29.

[5] Zhang Anxiong, LV Delong, Zhong Wei, et al. Blood Compatibility of Biomaterials, Shanghai Biomedical Engineering, 2004, 25(3): 53-58.

[6] Yan zhongsi, Wu zhengjun, Du Bin, Research progress on the pyrogen and Heat the bacterial endotoxin test, Chinese joumal of Medicalo recapitulate, 2005, 11(20): 142-144.

[7] Xu Jianxia, Wang Chunren, Xi Tingfei. In-vitro Evaluation of Haemocompatibility of Biomaterials. Journal of Biomedical Engineering, 2004, 21(5): 861-863.

[8] Meng Jie, Xu Haiyan. Developments in Understanding of Interactions between Blood and Biomaterials at Molecular and Cellular Levels. Journal of Biomedical Engineering, 2005, 22(6): 1271-1272.