Assessment of Blood and Tissue Compatibility of Dental Implant


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To evaluate the blood and tissue compatibility of the dental implant samples, the whole blood clotting time, prothrombin time and partial prothrombin time, hemolytic rate and local implantation tests of the dental implant samples were determined, which will provide the basis for the clinical safety of such medical products. The WBCT, PT and PTT results showed that there were no significant difference (p> 0.05)between the testing groups and the negative control group, hemolysis rate of the dental implant samples was 1.38%, less than 5%, which in line with medical equipment blood compatibility test, all of these results indicated that the dental implant had a good blood and tissue compatibility.



Edited by:

Liangzhong Jiang




J. Liu et al., "Assessment of Blood and Tissue Compatibility of Dental Implant", Advanced Materials Research, Vol. 590, pp. 95-99, 2012

Online since:

November 2012




[1] Gahyva SM, Siqueira J. Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems. [J] J Appl Oral Sci 2005; 13: 387-392.


[2] Xu Jianxia, Wang Chunren, Xi Tingfei. In-vitro Evaluation of Haemocompatibility of Biomaterials. J Biomed Eng 2004; 21(5): 861-863.

[3] Meng Jie, Xu Haiyan. Developments in understanding of interactions between blood and biomaterials at molecular and cellular levels. J Biomed Eng 2005, 22(6): 1271-1274.

[4] Zhang Anxiong, Lv Delong, Zhong Wei. Blood compatibility of biomaterials. Shanghai Journal of Biomedical Engineering. 2004; 25(3): 53-57.

[5] Michael VS, Cynthia HG, Maud BG. What really is blood compatibility. J Biomater Polymer Edn , 2000, 11(11): 1165-1118.

[6] ISO10993-4: Evaluation of medical devices-part 4: selection of tests for interactions with blood. [J] 2002, 2-10.

[7] Tian Jiajun, Zheng Hua, Wang Dingguo. Evaluation of blood compatibility of pdyeghersulfone hollow fiber dialyser for separation plasma. Bejing Journal of Biomedical Engineering. 2001; 20(3): 215-217.

[8] Sheng Jianling, Zhou Jufen. Tachypleus Amebocyte Lysate Test Using in Transfusion Reaction. Chinese Journal of Nosocomiology2009; 19 (8): 947-948.

[9] Yang Zhongsi, Wu Zhengjun, Du Bing. Progress in the detection of pyrogen and bacterial endotoxin2005; 11(2) : 142-144.