Layered reservoir systems present a huge challenge to both reservoir and production engineers, because of difficulty encountered in reservoir management and well completions. In this paper, the solution to a 2D reservoir model is utilized to study pressure and pressure derivatives of a two-layered crossflow reservoir with a vertical well. No skin and wellbore effects are included. The interlayer fluid transmissibility ratio is varied for the same layers properties, to study the effects of layers heterogeneity and well completion choice on flow performance. Results show that decreasing values of specific transmissibility ratio, , signifies completion in the more permeable layer, a shift in the pressure response to the left and a short transition period to depletion of the second layer. Furthermore, increasing values means that the well is completed in the lower permeability layer causing delay in the depletion of the second layer as a result of long transition period.