Directing Osteoblast Alignment and Elongation on the Micro-Grooved Silica-Based Hybrid Membrane
Silica-chitosan hybrid was synthesized from a mixture of chitosan and glycidyloxypropyltrimethoxysilane and then coated on a microgrooved polydimethylsiloxane (PDMS) mold to produce the microgrooved silica-chitosan hybrid membrane. After incubated with osteoblast-like MC3T3-E1 cells, the microgrooved hybrid membranes strongly directed the alignment and elongation of cells and exhibited a strong cell contact guidance ability, indicating a potential application as engineering bone tissue regenerative materials.
S. Chen and N. Hanagata, "Directing Osteoblast Alignment and Elongation on the Micro-Grooved Silica-Based Hybrid Membrane", Advanced Materials Research, Vol. 647, pp. 165-169, 2013