Impact of Nanopowders on Exraction Yield of Centella asiatica


Article Preview

Centella asiatica (C. Asiatica) is a traditional herb that has been used in raditional medicine especially in Asia region. Recently the pharmalogical study of Asiatic acid (AA) which is one of bioactive constituents in C. Asiatica has been studied and revealed that this compound has a potential to be use in medicine area. The objective of this paper is to produce nanoparticles C. Asiatica by Planetary Ball Mill (PBM) and determined the effect of nanonization on extraction yield of asiatic acid. The particles were analyzed using particle sizer to determine size of particle produce and the morphology was evaluated through FESEM. As a result, the mean particles size of nanopowders was 501.10 nm and the extraction of asiatic acid using nanopowders showed 82.09 % higher than original powder.



Edited by:

Mohamad Rusop Mahmood, Tetsuo Soga, Mohamad Hafiz Mamat, Zuraida Khusaimi and Asiah Mohd Nor




M.Z. Borhan et al., "Impact of Nanopowders on Exraction Yield of Centella asiatica", Advanced Materials Research, Vol. 667, pp. 246-250, 2013

Online since:

March 2013




[1] B. S. Siddiqui, H. Aslam, S. T. Ali, S. Khan, S. Begum, Chemical constituents of Centella asiatica, Journal of Asian Natural Products Research 9 (2007) 407-414.


[2] T. D. Babu, G. Kuttan, J. Padikkala, Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L. ) Urban, Journal of Ethnopharmacology 48 (1995) 53-57.


[3] G. Jayashree, G. Kurup Muraleedhara, S. Sudarslal, V. B. Jacob, Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice, Fitoterapia 74 (2003) 431-434.


[4] S. G. Jin, L. C. Chuen, M. W. L. Koo, Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats, Planta Medica 70 (2004) 1150-1154.


[5] F. Kesisoglou, S. Panmai, Y. Wu, Nanosizing - Oral formulation development and biopharmaceutical evaluation, Advanced Drug Delivery Reviews 59 (2007) 631-644.


[6] Y. L. Su, Z. Y. Fu, J. Y. Zhang, W. M. Wang, H. Wang, Y. C. Wang, and Q. J. Zhang, Fabrication and physiochemical characterization of nano Panax notoginseng particles, Nanoscience 11 (2006) 258-264.

[7] P. K. Inamdar, R. D. Yeole, A. B. Ghogare, and N. J. De Souza, Determination of biologically active constituents in Centella asiatica, Journal of Chromatography A 742 (1996) 127-130.


[8] Y. L. Su, Z. Y. Fu, W. M. Wang, H. Wang, Y. C. Wang, J. Y. Zhang, P. Y. Ma, Ultrafine grinding of Radix salvia miltiorrhiza particles and the physicochemical properties by high speed centrifugal sheering, " vol. 330-332 I, ed, 2007, 215-218.


[9] A. A. Noyes and W. R. Whitney, The rate of solution of solid substances in their own solutions, The Journal of the American Chemical Society 19 (1897) 930-934.


[10] Y. L. Su, Z. Y. Fu, C. J. Quan, and W. M. Wang, Fabrication of nano Rhizama Chuanxiong particles and determination of tetramethylpyrazine, Transactions of Nonferrous Metals Society of China 16 (2006) S393-S397.