Biomechanics of Synthetic Elastin: Insights from Magnetic Resonance Microimaging


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We used Magnetic Resonance microimaging (MRI) to study the compressive behaviour of synthetic elastin. Compression-induced changes in the elastin sample were quantified using longitudinal and transverse spin relaxation rates (R1 and R2, respectively). Spatially-resolved maps of each spin relaxation rate were obtained, allowing the heterogeneous texture of the sample to be observed with and without compression. Compression resulted in an increase of both the mean R1 and the mean R2, but most of this increase was due to sub-locations that exhibited relatively low R1 and R2 in the uncompressed state. This behaviour can be described by differential compression, where local domains in the hydrogel with a relatively low biopolymer content compress more than those with a relatively high biopolymer content.



Edited by:

Jin Yun and Dehuai Zeng






K. I. Momot et al., "Biomechanics of Synthetic Elastin: Insights from Magnetic Resonance Microimaging", Advanced Materials Research, Vol. 699, pp. 457-463, 2013

Online since:

May 2013




[1] S.M. Mithieux, J.E.J. Rasko and A.S. Weiss: Biomaterials Vol. 25 (2004) p.4921.

[2] K.I. Momot: Biomedical Spectroscopy and Imaging Vol. 1 (2012) p.27.

[3] S.K. de Visser, J.C. Bowden, E. Wentrup-Byrne, L. Rintoul, T. Bostrom, J.M. Pope and K.I. Momot: Osteoarthr. Cartilage Vol. 16 (2008) p.689.

DOI: 10.1016/j.joca.2007.09.015

[4] C. Naumann, S.M. Mithieux, D. Szekely, Y. Tu, A.S. Weiss and P.W. Kuchel: Biopolymers Vol. 91 (2009) p.321.

[5] S.H. Koenig and R.D. Brown III, in: Encyclopedia of nuclear magnetic resonance, edited by D.M. Grant, R.K. Harris, Wiley, New York (1996).

[6] K.I. Momot, J.M. Pope and R.M. Wellard: NMR Biomed. Vol. 23 (2010) p.313.

[7] J. Sandstroem: Dynamic NMR spectroscopy, Academic Press, London, (1982).

[8] B. Li, D.O.V. Alonso, B.J. Bennion and V. Daggett: J. Am. Chem. Soc. Vol. 123 (2001) p.11991.

[9] A. Abragam: Principles of nuclear magnetism, Clarendon Press, Oxford, (1961).

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