In Vivo Biocompatibility Studies of Nano TiO2 Materials


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TiO2 nanomaterials with different dimensions(zero and one), sizes(20nm, 50nm and 100nm in diameter) and crystal structures(100% rutile, 100% anatase and combination of 20% rutile and 80% anatase) were confected to suspensions and ointment with varied concentrations and evaluated in animal model (Balb-c mouse). These mouse were divided into various groups randomly, with suspension intraperitoneally injected or ointment transdermally daubed. Heart, lung, liver and kidney were collected and prepared to HE sample after one week. Spectrophotometry was applied to study total antioxide capability and catalase activity of blood and tissues. It has been shown that all TiO2 nanomaterial groups had no effect on lives’ morphology and oxidative stress, with no obvious histopathological changes observed in heart, lung, liver and kidney, and these tissues presented no vacuolar degeneration, necrosis edema, engorgement and inflammation.



Advanced Materials Research (Volumes 79-82)

Edited by:

Yansheng Yin and Xin Wang






W. Han et al., "In Vivo Biocompatibility Studies of Nano TiO2 Materials", Advanced Materials Research, Vols. 79-82, pp. 389-392, 2009

Online since:

August 2009




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