Electrophoretic Deposition and Characterization of Biocomposites on Magnesium for Orthopedic Applications

Abstract:

Article Preview

The objective of this study is to produce a uniform and consistent nanophase hydroxyapatite (nHA) and poly (lactic-co-glycolic acid) (PLGA) coating on three-dimensional magnesium (Mg) implants using electrophoretic deposition (EPD) process. Mg is biodegradable, mechanically strong, and promising for orthopedic implant and device applications. However, currently available Mg and its alloys degrade too rapidly to meet clinical needs. To control Mg degradation and promote bone ingrowth, nHA/PLGA composite microspheres were synthesized and deposited onto Mg substrates using EPD process. Annealing was applied to improve the coating adhesion. The surface morphology, composition, and coating cross-section were examined using a scanning electron microscope and energy dispersive X-ray spectrometer. The results showed the presence of calcium, phosphorous, carbon, and oxygen peaks, indicating the successful deposition of nHA/PLGA microspheres on Mg. The corrosion resistance of the coated Mg was evaluated using the Tafel test. The results showed that the nHA/PLGA composite coating improved the corrosion resistance of Mg.

Info:

Periodical:

Edited by:

B. Mishra, M. Ionescu and T. Chandra

Pages:

761-766

Citation:

Q. M. Tian and H. N. Liu, "Electrophoretic Deposition and Characterization of Biocomposites on Magnesium for Orthopedic Applications", Advanced Materials Research, Vol. 922, pp. 761-766, 2014

Online since:

May 2014

Export:

Price:

$38.00

* - Corresponding Author

[1] Johnson, I., D. Perchy, and H. Liu, In vitro evaluation of the surface effects on magnesium-yttrium alloy degradation and mesenchymal stem cell adhesion. Journal of Biomedical Materials Research Part A, 2012. 100A(2): pp.477-485.

DOI: https://doi.org/10.1002/jbm.a.33290

[2] Posner, A.S., Crystal chemistry of bone mineral. Physiological reviews, 1969. 49(4): pp.760-792.

[3] Lock, J., T.Y. Nguyen, and H. Liu, Nanophase hydroxyapatite and poly(lactide-co-glycolide) composites promote human mesenchymal stem cell adhesion and osteogenic differentiation in vitro. Journal of Materials Science: Materials in Medicine, 2012. 23(10): pp.2543-2552.

DOI: https://doi.org/10.1007/s10856-012-4709-0

[4] Liu, H. and T.J. Webster, Ceramic/polymer nanocomposites with tunable drug delivery capability at specific disease sites. Journal of Biomedical Materials Research Part A, 2010. 93(3): pp.1180-1192.

DOI: https://doi.org/10.1002/jbm.a.32614

[5] Jevtic, M., et al., Controlled assembly of poly(d, l-lactide-co-glycolide)/hydroxyapatite core–shell nanospheres under ultrasonic irradiation. Acta Biomaterialia, 2009. 5(1): pp.208-218.

DOI: https://doi.org/10.1016/j.actbio.2008.07.026

[6] McGinity, J.W. and P.B. O'Donnell, Preparation of microspheres by the solvent evaporation technique. Adv Drug Deliv Rev, 1997. 28(1): pp.25-42.

[7] Sarkar, P., et al., Electrophoretic Deposition (EPD): Fundamentals and Novel Applications in Fabrication of Advanced Ceramic Microstructures. 2012: pp.181-215.

DOI: https://doi.org/10.1007/978-1-4419-9730-2_5

[8] Besra, L. and M. Liu, A review on fundamentals and applications of electrophoretic deposition (EPD). Progress in Materials Science, 2007. 52(1): pp.1-61.

DOI: https://doi.org/10.1016/j.pmatsci.2006.07.001

[9] Sarkar, P. and P.S. Nicholson, Electrophoretic deposition (EPD): Mechanisms, kinetics, and application to ceramics. Journal of the American Ceramic Society, 1996. 79(8): p.1987-(2002).

DOI: https://doi.org/10.1111/j.1151-2916.1996.tb08929.x

[10] Xw Meng, T. -Y.K. (2006) Effects of applied voltages on hydroxyapatite coating of titanium by elecctrophoretic deposition. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2006. 78: pp.373-377.

[11] Iqbal, N., et al., Electrophoretic deposition of PVA coated hydroxyapatite on 316L stainless steel. Current Applied Physics, 2012. 12(3): pp.755-759.

DOI: https://doi.org/10.1016/j.cap.2011.11.003

[12] Lin, C., et al., Electrophoretic deposition of HA/MWNTs composite coating for biomaterial applications. Journal of Materials Science: Materials in Medicine, 2007. 19(7): pp.2569-2574.

DOI: https://doi.org/10.1007/s10856-007-3196-1