Fabrication of Gold Cap-Shaped Nano-Particle Films and Sensing Device for Bioanalytical Application
The nano biosensors based on gold cap-shaped nano-particles like polystyrene and silica nanospheres have been successfully prepared on the substrates of disposable plate (96 wells) and miniplate (72 wells). The sensing film of carboxymethyl dextran layer was modified on the gold surface of the cap-shaped nano-particles. The corresponding micro-device with four channel of optical sensing system has been well constructed and applied to detection of anti-avidin D protein and biotinylated DNA molecules. The DNA hybridization reaction has also been real-time and parallel monitored in four channels, showing that the device possessed a nice reproducibility, which opens a promising bioanalytical application in practice.
Zhengyi Jiang and Chunliang Zhang
Z. Cao et al., "Fabrication of Gold Cap-Shaped Nano-Particle Films and Sensing Device for Bioanalytical Application", Advanced Materials Research, Vols. 97-101, pp. 2188-2191, 2010