Bacterial issues in ophthalmic applications, with particular reference to postoperative infection of ocular implants, cause significant problems that often require additional, stressful and expensive treatments for the patients. In this work we applied silver-containing antibacterial costings on two kinds of polymeric ocular devices, i.e. silicone scleral buckles for retinal detachment surgery and poly(methyl methacrylate) artificial eyes for enucleated patients. The coatings (thickness around 50 nm), constituted by silver nanoclusters embedded in a silica matrix, were produced by RF co-sputtering and investigated by SEM and EDS. The antibacterial effect of the coating was confirmed by the in vitro formation of an inhibition halo against Staphylococcus aureus, which is one of the most common pathogens involved in ocular infections. The approach proposed in this study for treating implant-related ocular infections can have a significant impact in the field of ophthalmic biomaterials, suggesting a valuable alternative to the administration of antibiotics that may become ineffective towards resistant bacterial strains.