Fabrication and In-Vitro Characterization of Three-Dimensional Composite Scaffolds by Robocasting for Biomedical Applications


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The development of novel biodegradable scaffolds for the treatment of bone and cartilage defects is the subject of intense research. A successful scaffold will guide cell-attachment, proliferation and tissue regeneration. The objective of this study is to use freeform fabrication (robocasting) for the preparation of porous hybrid organic/inorganic materials with a well controlled architecture and porosity. Polymer/hydroxyapatite (HA) pastes with ceramic contents ranging between 0 to 70 wt. % are prepared by mixing ceramic powders with a solution of the polymer in methylene chloride. Two different polymers are studied: polylactide (PLA) and polycaprolactone (PCL). During the compression tests, the scaffolds show an elasto-plastic behavior with large plastic yielding and do not fail in a brittle manner. The mechanical response is anisotropic and depends significantly on the ceramic content and the type of polymer.



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J. Russias et al., "Fabrication and In-Vitro Characterization of Three-Dimensional Composite Scaffolds by Robocasting for Biomedical Applications", Advances in Science and Technology, Vol. 49, pp. 153-158, 2006

Online since:

October 2006




[1] D. W. Hutmacher, Biomaterials, 2000, 21, 2529.

[2] R. F. Service, Science, 2000, 289, 1498.

[3] K. J. L. Burg, S. Porter, J. F. Kellam, Biomaterials, 2000, 21, 2347.

[4] W. Cheng, H. Y. Li, J. Chang, Materials Letters, 2005, 59, 2214.

[5] A. M. A. Ambrosio, J. S. Sahota, Y. Khan, C. T. Laurencin, Journal of Biomedical Materials Research, 2001, 58, 295.

[6] L. M. Matthieu et al., Biomaterials, 2006, 27, 905.

[7] D. W. Hutmacher, M. Sittinger, M. V. Risbud, Trends in Biotechnology, 2004, 22, 354.

[8] G. Vozzi, C. Flaim, A. Ahluwalia, S. Bhatia, Biomaterials, 2003, 24, 2533.

[9] S. J. Kalita, S. Bose, H. L. Hosick, A. Bandyopadhyay, Materials Science & Engineering CBiomimetic and Supramolecular Systems, 2003, 23, 611.

[10] I. Grida, J. R. G. Evans, Journal of the European Ceramic Society, 2003, 23, 629.

[11] J. H. Kinney, M. C. Nichols, Annual Review of Materials Science, 1992, 22, 121.

[12] T. kokubo, H. Kushitani, S. Sakka, T. Kitsugi, T. Yamamuro, Journal of Biomedical Materials Research, 1990, 24, 721.

[13] P. B. ODonnell, J. W. McGinity, Advanced Drug Delivery Reviews, 1997, 28, 25.

[14] S. J. Hollister, Nature Materials, 2005, 4, 518.

[15] J. E. Smay, J. Cesarano, J. A. Lewis, Langmuir, 2002, 18, 5429.

[16] S. Michna, W. Wu, J. A. Lewis, Biomaterials, 2005, 26, 5632.

[17] E. Luong-Van et al., Biomaterials, 2006, 27, (2042).

[18] R. Murugan, S. Ramakrishna, Composites Science and Technology, 2005, 65, 2385.

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