Fabrication and In-Vitro Characterization of Three-Dimensional Composite Scaffolds by Robocasting for Biomedical Applications
The development of novel biodegradable scaffolds for the treatment of bone and cartilage defects is the subject of intense research. A successful scaffold will guide cell-attachment, proliferation and tissue regeneration. The objective of this study is to use freeform fabrication (robocasting) for the preparation of porous hybrid organic/inorganic materials with a well controlled architecture and porosity. Polymer/hydroxyapatite (HA) pastes with ceramic contents ranging between 0 to 70 wt. % are prepared by mixing ceramic powders with a solution of the polymer in methylene chloride. Two different polymers are studied: polylactide (PLA) and polycaprolactone (PCL). During the compression tests, the scaffolds show an elasto-plastic behavior with large plastic yielding and do not fail in a brittle manner. The mechanical response is anisotropic and depends significantly on the ceramic content and the type of polymer.
P. VINCENZINI and R. GIARDINO
J. Russias et al., "Fabrication and In-Vitro Characterization of Three-Dimensional Composite Scaffolds by Robocasting for Biomedical Applications", Advances in Science and Technology, Vol. 49, pp. 153-158, 2006