Bioactive and Biocompatible Silica/Pseudowollastonite Aerogels


Article Preview

Silica aerogels have attracted increasingly more attention due to their extraordinary properties and their existing and potential applications in a wide variety of technological areas. Materials that promote bone-tissue formation at their surface and bond to osseous tissues when implanted are called bioactive, such as pseudowollastonite particles. In this work, the synthesis of aerogels with pseudowollastonite particles was performed. The synthesis involved the preparation of an alcogel by a two step sol-gel route followed by ambient pressure drying. To promote a higher bioactivity the obtained aerogels were then biomimetically treated using simulated body fluids, SBF and 1.5 SBF. A high bioactivity was demonstrated by FT-IR, SEM, EDS, and XRD. The in vitro biocompatibility was assessed by testing cytotoxicity using rat osteoblasts cultures. The results obtained indicate that these materials are highly potential aerogels for bone tissue regeneration.



Edited by:

Pietro Vincenzini






P.J. Reséndiz-Hernández et al., "Bioactive and Biocompatible Silica/Pseudowollastonite Aerogels", Advances in Science and Technology, Vol. 96, pp. 21-26, 2014

Online since:

October 2014




[1] Andrade, A. L., Valerio, P., Goes, A. M., Leite, M. F., & Domingues, R. Z. Influence of morphology on in vitro compatibility of bioactive glasses. Journal of Non- Crystalline Solids, 352, (2006) 3508–3511.

DOI: 10.1016/j.jnoncrysol.2006.03.105

[1] .

[2] J. A. Toledo-Fernández, R. Mendoza-Serna, V. Morales-Flórez, N. de la Rosa–Fox, A. Santos, M. Piñero, L. Esquivias. Aerogeles con aplicaciones en biomedicina y medioambiente. Bol. Soc. Esp. Ceram. V. 46(3) (2007) 138.

DOI: 10.3989/cyv.2007.v46.i3.246

[3] Hench, L. L Biomaterials: a forecast for the future., Biomaterials, 19(16) (1998) 1419-1423.

DOI: 10.1016/s0142-9612(98)00133-1

[4] Cortés, D. A; Nogiwa, A. A; Almanza, J. M; Ortega, S: Biomimetic apatite coating on Mg-PSZ/Al2O3 composites. Effect of the immersion method, Mat. Lett., 59, (2005)1352-1355.

DOI: 10.1016/j.matlet.2004.12.040

[5] Jyoti, L; Gurav, A; Digambar, Y; Nadargi, A; Venkateswara, Rao: Effect of mixed Catalysts system on TEOS-based silica aerogels dried at ambient pressure, Appl Surf Sci., 255 (2008) 3019–3027.

DOI: 10.1016/j.apsusc.2008.08.059

[6] Jyoti, L; Gurav, A; Venkateswara, Rao; Uzma Bangi, K. H: Hydrophobic and low density silica aerogels dried at ambient pressure using TEOS precursor., J Alloy Compd., 471, (2009) 296-302.

DOI: 10.1016/j.jallcom.2008.03.076

[7] Martínez, I. M; Velásquez, P; Meseguer-Olmo, L; Aza, P. N. de: Production and study of in vitro behavior of monolithic a –tricalcium phosphate based ceramics in the system Ca3 (PO4)2–Ca2SiO4., Ceram Int., 37(7), (2011)2527-2535.

DOI: 10.1016/j.ceramint.2011.03.062

[8] Brinker, C. J; Sherer, G. W: Sol Gel science, The Physics and Chemistry of Sol-Gel Processing. Acad. Press, New York (1990).

[9] Kokubo, T; Shigematsu, M; Nagashima, Y; Tashimiro, M; Nakamura, T; Yamamuro, T; Hagasho, S: Apatite and Wollastonite containing glass ceramics for prosthetic applications., Bull Inst Chem Res, Kyoto Univ. 60, (1982) 3-4.

[10] Lukito, D; Xue, J. M; Wang, J: In vitro bioactivity assessment of 70 (wt. )%SiO2–30 (wt. )%CaO bioactive glasses in simulated body fluid, Mater Lett., 59, (2005) 3267-3271.

DOI: 10.1016/j.matlet.2005.05.055

[11] Rao, A. V; Gurav, A. B; Latthe, S. S; Vhatkar, R. S; Imai, H; Kappenstein, C; Wagh, P. B; Gupta: Water repellent porous silica films by sol-gel dip coating method, J Colloid Interf Sci., 352(1), (2010) 30-35.

DOI: 10.1016/j.jcis.2010.08.003

[12] Nogiwa, A. A; Cortés, D. A: Bone-like apatite coating on Mg-PSZ/Al2O3 composites using bioactive systems, J Mater Sci: Mater M., 17, (2006) 1139-1144.

DOI: 10.1007/s10856-006-0541-8

[13] Carlisle E.M. Silicon: a possible factor in bone calcification. Science 167 (1970), 179.

[14] Carlisle E.M. Silicon: a requirement in bone formation independent of vitamin D1. Calc. Tissue. Int, 33 (1981) 27.

In order to see related information, you need to Login.