A Brief Review of the Modelling of the Time Dependent Mechanical Properties of Tissue Engineering Scaffolds

Abstract:

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The functionality of tissue scaffolds in vivo plays a critical role in the treatment process. Due to the time dependent nature of the mechanical properties of the constituent phases of the scaffold, a wide range of mechanical property histories may be observed during the treatment process, possibly influencing outcomes. The critical nature of the mechanical properties in load bearing applications indicates a need for the simultaneous modelling of both scaffold degradation and tissue regeneration with time, and the resulting effective properties of the tissue engineering construct. To this end, a review of the literature is conducted to identify the various existing approaches to modelling scaffold degradation, tissue behavior, and the dependency of the two processes on one another.

Info:

Pages:

19-33

DOI:

10.4028/www.scientific.net/JBBTE.6.19

Citation:

N.K. Bawolin et al., "A Brief Review of the Modelling of the Time Dependent Mechanical Properties of Tissue Engineering Scaffolds", Journal of Biomimetics, Biomaterials and Tissue Engineering, Vol. 6, pp. 19-33, 2010

Online since:

September 2010

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Price:

$35.00

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