A Brief Review of the Modelling of the Time Dependent Mechanical Properties of Tissue Engineering Scaffolds
The functionality of tissue scaffolds in vivo plays a critical role in the treatment process. Due to the time dependent nature of the mechanical properties of the constituent phases of the scaffold, a wide range of mechanical property histories may be observed during the treatment process, possibly influencing outcomes. The critical nature of the mechanical properties in load bearing applications indicates a need for the simultaneous modelling of both scaffold degradation and tissue regeneration with time, and the resulting effective properties of the tissue engineering construct. To this end, a review of the literature is conducted to identify the various existing approaches to modelling scaffold degradation, tissue behavior, and the dependency of the two processes on one another.
N.K. Bawolin et al., "A Brief Review of the Modelling of the Time Dependent Mechanical Properties of Tissue Engineering Scaffolds", Journal of Biomimetics, Biomaterials and Tissue Engineering, Vol. 6, pp. 19-33, 2010