Biogenic Silver Nanoparticles and its Antifungal Activity as a New Topical Transungual Drug
Silver nanoparticles production was monitored by UVVis and TEM micrograph and they were obtained as spherical and homogenous nanoparticles with a size of ~100 nm by photon correlation spectroscopy (PCS). Silver nanoparticles, in an IC80 range of 1-2 μg/mL, showed significant antifungal activity against T. rubrum. Cytotoxicity through hemolytic activity against erythrocytes and the viability of V79 fibroblast or HL60 cells showed less toxicity than amphotericin B. The disk diffusion test showed that the silver nanoparticles exerted a similar inhibition zone that amphotericin B by a synergistic effect when added at the same time against T. rubrum culture.
P. D. Marcato et al., "Biogenic Silver Nanoparticles and its Antifungal Activity as a New Topical Transungual Drug", Journal of Nano Research, Vol. 20, pp. 99-107, 2012