Stress control of the growth-strain method was applied to shape optimization of multiple cutouts in laminated composite plates. Since the growth-strain method optimizes a shape by generating the bulk strain to make the distributed parameter uniform, the distributed parameter was chosen as Tsai-Hill value, as volume control of the growth-strain method. In this study, of particular interest is to see whether stress control of the growth-strain method developed for shape optimization in isotropic media would work for laminated composite plates. The shapes optimized by Tsai-Hill fracture index were compared with those of the initial shapes for the various load conditions. As a result, it was verified that stress control of the growth-strain method also worked very well for multiple cutouts optimization in laminated composite plates.