Structural Comparison of Ligand-Binding Domains in Estrogen-Related Receptors


Article Preview

Estrogen-related receptors (ERRs), orphan nuclear receptors, share a significant amino acid sequence homology with estrogen receptors (ERs), yet their ligands do not respond in the same manner. In fact, some of the ligands that are known as agonists of ERs show antagonistic effect in ERRs. Accordingly, the current study investigated the structures of the ligand-binding domains using homology model building and docking studies. The results showed clear differences between the ligand-binding pockets of ERRs and ERs, thereby providing structural insights into the activities related to the ligands.



Key Engineering Materials (Volumes 277-279)

Edited by:

Kwang Hwa Chung, Yong Hyeon Shin, Sue-Nie Park, Hyun Sook Cho, Soon-Ae Yoo, Byung Joo Min, Hyo-Suk Lim and Kyung Hwa Yoo




H. Y. Kim et al., "Structural Comparison of Ligand-Binding Domains in Estrogen-Related Receptors", Key Engineering Materials, Vols. 277-279, pp. 107-112, 2005

Online since:

January 2005




[1] W. Xie, H. Hong, N. N. Yang, R. J. Lin, C. M. Simon, M. R. Stallcup and R. M. Evans: Mol. Endocrinol. Vol. 12 (1999), p.2151.

[2] H. Hong, L. Yang and R. M. Stallcup: J. Biol. Chem. Vol. 274 (1999), p.22618.

[3] V. Giguere: Endocr. Rev. Vol. 20 (1999), p.689.

[4] V. Giguere, N. Yang, P. Segui, R. M. Evans: Nature Vol. 331 (1988), p.91.

[5] V. Giguere: Trends Endocrinol Metab. Vol. 13 ( 2002), p.220.

[6] G. B. Tremblay, T. Kunath, D. Bergeron, L. Lapointe, C. Champigny, J. -A. Bader, J. Rossant and V. Giguere: Genes Dev. Vol. 15 (2001), p.833.

[7] P. Coward, D. Lee, M. V. Hull and J. M. Lehmann: Proc Natl Acad Sci U S A. Vol. 98 (2001), p.8880.

[8] G. B. Tremblay, D. Bergeron and V. Giguere: Endocrinology. Vol. 142 (2001), p.4572.

[9] C. Yang and S. Chen: Cancer Research Vol. 59 (1999), p.4519.

[10] A. K. Shiau, D. Barstad, P. M. Loria, L. Cheng, P. J. Kushner, D. A. Agard and G. L. Greene: Cell Vol. 95 (1998), p.927.

[11] H. Greschik, J. -M. Wurtz, S. Sanglier, W. Bourguet, A. van Dorsselaer, D. Moras and J. -P. Renaud: Molecular Cell Vol. 9 (2002), p.303.

[12] S. Chen, D. Zhou, C. Yang and M. Sherman: J. Biol. Chem. Vol. 276 (2001), p.28465.