Enhanced Transdermal Delivery of Local Anesthetics by Liposome Formulation of Local Anesthetic Mixture


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Various concentrations of either lidocaine or tetracaine, plus combinations of lidocaine and tetracaine were formulated into liposomes to improve topical anesthesia. The topical anesthetic effects of these liposomal mixtures of local anesthetics (Lipo-MLA) were then compared with those of EMLA (Eutectic Mixture of Local Anesthetics) and single local anesthetic liposomes using a pinprick test on healthy adult volunteers. The Lipo-MLA exhibited significantly improved anesthetic effects compared to the EMLA and single local anesthetic liposomes with a faster onset time of approximately thirty minutes and duration of at least four hours. A dermal toxicity study using rats revealed that Lipo-MLA was safe at greater than 2,000 mg/kg bodyweight.



Key Engineering Materials (Volumes 277-279)

Edited by:

Kwang Hwa Chung, Yong Hyeon Shin, Sue-Nie Park, Hyun Sook Cho, Soon-Ae Yoo, Byung Joo Min, Hyo-Suk Lim and Kyung Hwa Yoo




J. O. Lim et al., "Enhanced Transdermal Delivery of Local Anesthetics by Liposome Formulation of Local Anesthetic Mixture ", Key Engineering Materials, Vols. 277-279, pp. 45-50, 2005

Online since:

January 2005




[1] B. Bingham, M. Hawke and J. Halik: J Otolaryngol Vol. 20 (1991), pp.193-195.

[2] J. Luotonen, K. Laitakari, H. Karjalanen and K. Jokinen: Acta Otolaryngol Vol. 462 (1992), pp.63-67.

[3] A.N. Lars, B. Peter: Anesth Analg Vol. 67 (1988), pp.115-123.

[4] B. Hallen, G. L. Ohlsen and A. Uppfeldt: Anesthesia Vol. 39 (1984), pp.969-972.

[5] M. Foldvari, A. Gesztes and M. Mezei: J Microencapsul Vol. 7 (1990), pp.479-489.

[6] D.F. MaCafferty, A.D. Woolfson, K. McClelland and V. Boston: Br J Anaesth Vol. 60 (1988), pp.64-69.

[7] A.W. Chan, I.A. MacFarlane, D. Bowsher and J.A. Campbell: J Neurol Neurosurg Psychiat Vol 56 (1992), pp.56-59.

[8] D. Brian, J. Edward and L. Ronal: Dermatol Surg Vol 24 (1998), pp.537-541.

[9] G.R. Strichartz, V. Sanchez and G.R. Arthur: Anesth Analg Vol 71 (1990), pp.158-162.

[10] M. G. Ganesan, N.D. Weiner, G. L. Flynn, K. F. H. Ho: Int J Pharm Vol. 20 (1984), pp.139-154.

[11] J. Goto, H. Araki, S. Otomo, H. Aihara: Drugs Exp Clin Res Vol. 12 (1986), pp.917-921.

[12] B.D. Bucalo, E.J. Mirikitani, R.L. Moy: Dermatol Surg Vol. 24 (1998), pp.537-541.