Biphasic and Preferentially Oriented Microcrystalline Calcium Phosphate Coatings: In Vitro and In Vivo Studies
We report results of in-vitro and in-vivo studies on biphasic thin film coatings of hydroxyapatite/tetracalcium phosphate produced by pulsed laser deposition using ablation targets of crystalline hydroxyapatite. Changes in coating phase composition during in-vitro dissolution experiments were monitored by x-ray diffraction. Scanning electron microscopy was used to assess variations in surface morphology. In-vivo experiments involving the insertion of coated metallic implants in the proximal tibia and distal femur of New Zealand White Rabbits were carried out. Histomorphometric studies on implant samples after surgical extraction show that biphasic coatings produced may lead to enhanced osteointegration compared to pure hydroxyapatite coatings.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
H. B. Kim et al., "Biphasic and Preferentially Oriented Microcrystalline Calcium Phosphate Coatings: In Vitro and In Vivo Studies ", Key Engineering Materials, Vols. 284-286, pp. 207-210, 2005