Confined Compression of Bone Substitute Granules


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This study investigated the strength of several bone graft substitute (BGS) granular products under compression in a confined fixture characteristic of packing into a contained surgical bone defect. The compressive strength values for columns of granules made of tricalcium phosphate (TCP, dense), calcium carbonate / hydroxyapatite (CC/HA, porous) and ultraporous TCP (TCPu, ultra porous) were 2063.8 ±177.6N, 115.3 ±7.4N, and 40.5 ±8.3, respectively. As a result of their higher strength, the TCP granules did not appreciably reduce in volume after packing. The CC/HA and TCPu granules appreciably reduced in volume after packing, with the final packed volumes being 68% and 41%, respectively, of their original volumes. Based on these results the TCP synthetic bone substitute granules are better able to resist crushing and retain their original volume and osteoconductive capacity during packing in a bone defect than the other BGS granules tested in this study. These properties give the dense granules with a six-arm, interlocking shape superior robustness during handling and implantation compared to other BGS scaffolds produced by porous granules, morsels or blocks, while producing a comparable osteoconductive, resorbable scaffold with interconnected porosity.



Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.




M. Long et al., "Confined Compression of Bone Substitute Granules ", Key Engineering Materials, Vols. 284-286, pp. 361-364, 2005

Online since:

April 2005




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[10] [20] [30] [40] [50] [60] [70] [80] [90] 100 TCP CC/HA TCPu Volume Filled After Packing Relative to Original Volume (%).