In Vitro Behavior of Yttrium Silica Sol-Gel Microspheres

Abstract:

Article Preview

Biodegradable silica microspheres containing neutron activable yttrium cations were investigated as a potential material for in situ radiotherapy of cancers. The sol-gel method used for preparing the microspheres allows obtaining at relative low temperatures materials of high purity and homogeneity, with controlled rate of biodegradability. The influence of yttrium on the biodegradability of the silica microspheres was studied in a simulated body fluid (SBF). The chemical durability of the microspheres was investigated under in vitro conditions and the concentration of yttrium released from the microspheres was determined.

Info:

Periodical:

Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.

Pages:

411-414

DOI:

10.4028/www.scientific.net/KEM.284-286.411

Citation:

D. Cacaina et al., "In Vitro Behavior of Yttrium Silica Sol-Gel Microspheres ", Key Engineering Materials, Vols. 284-286, pp. 411-414, 2005

Online since:

April 2005

Export:

Price:

$35.00

[1] L.L. Hench and J. Wilson: An Introduction to Bioceramics (World Scientific, Singapore, 1993).

[2] H. Ylänen, K. Karlsson, A. Itala and H.T. Aro: J. of Non Cryst. Solids 275(1-2) (2000), pp.107-115.

[3] W.S. Roberto, M.M. Pereira and T.P.R. Campos: Artificial Organs 27(5) (2003), pp.420-424.

[4] U.O. Häfeli, W.K. Roberts, G.J. Pauer, S.K. Kraeft and R.M. Macklis: Applied Radiation and Isotopes 54 (2001), pp.869-879.

[5] J.E. White and D.E. Day: Key Engineering Materials 94-95 (1994), pp.181-208.

[6] D. Cacaina, S. Simon, H. Ylänen and M. Hupa: Journal of Materials Science, Materials in medicine (submitted).

[7] T. Kokubo, H. Kushitani, S. Saka, T. Kitsugi and T. Yamamuro: J. Biomed. Mater. Res. 24 (1990), pp.721-734. Fig. 3 Ca and P concentrations variation in SBF versus immersion time: (a) 7Y0 sample and (b) 20Y0 sample.

In order to see related information, you need to Login.