In Vitro Behavior of Yttrium Silica Sol-Gel Microspheres
Biodegradable silica microspheres containing neutron activable yttrium cations were investigated as a potential material for in situ radiotherapy of cancers. The sol-gel method used for preparing the microspheres allows obtaining at relative low temperatures materials of high purity and homogeneity, with controlled rate of biodegradability. The influence of yttrium on the biodegradability of the silica microspheres was studied in a simulated body fluid (SBF). The chemical durability of the microspheres was investigated under in vitro conditions and the concentration of yttrium released from the microspheres was determined.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
D. Cacaina et al., "In Vitro Behavior of Yttrium Silica Sol-Gel Microspheres ", Key Engineering Materials, Vols. 284-286, pp. 411-414, 2005