Using X-Ray Micro-CT Imaging to Monitor Dissolution of Macroporous Bioactive Glass Scaffolds
Bioactive glass scaffolds with interconnected macroporous networks have been developed by foaming sol-gel derived bioactive glass of the 70S30C (70 mol% SiO2, 30 mol% CaO) composition. The effect of sintering temperature on the dissolution of the scaffolds in simulated body fluid (SBF) was investigated in 3D using x-ray micro-computer tomography (micro CT) and inductive coupled plasma (ICP) analysis. Micro-CT is non-destructive and allows observation of specific parts of the scaffold at various stages of degradation. However, data analysis is complex at present. Percentage porosity data obtained by micro-CT was compared to physical data and pore size distributions obtained from mercury intrusion porosimetry were compared to the interconnected pore diameters observed from the micro CT images.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
J. R. Jones et al., "Using X-Ray Micro-CT Imaging to Monitor Dissolution of Macroporous Bioactive Glass Scaffolds ", Key Engineering Materials, Vols. 284-286, pp. 493-496, 2005