In Vivo Evaluation of Porous Hydroxyapatite/Poly D/L-Lactide Composite for Bone Substitute and Scaffold
We investigated the biocompatibility, osteoconductivity, and biodegradability of porous composite of Hydroxyapatite (HA) and Poly D/L-lactide (PDLLA). At 6weeks afterimplantation to rabbit femoral condyle, HA/PDLLA was covered with bone and contacted with bone directly. The amounts of newly formed bone in the pores had increased during the examined period. By 26weeks, bone remodeling of formed bone in the pores was seen and bone marrow tissue formation was seen in the pores of HA/PDLLA. Porous HA/PDLLA was resorbed much faster than porous HA as a control. Porous HA/PDLLA was resorbed constantly through the bone formation and bone remodeling but porous HA was hardly resorbed during the period. It might be one of the desirable materials for bone substitute. To evaluate for a scaffold, disc shaped blocks loaded with rat bone marrow cell were implanted in the subcutaneous pouch of the back of syngeneic rat. At 3weeks afterimplantation, newly bone formation in the pores was observed at ectopic site. It also suggested the availability of this material as cell scaffolds.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
S. Hasegawa et al., "In Vivo Evaluation of Porous Hydroxyapatite/Poly D/L-Lactide Composite for Bone Substitute and Scaffold ", Key Engineering Materials, Vols. 284-286, pp. 769-774, 2005