Preparation of Porous Poly(Lactic Acid)/Hydroxyapatite Microspheres Intended for Injectable Bone Substitutes


Article Preview

Porous biodegradable microspheres were successfully obtained by an improvement single step and surfactant-free emulsion solvent evaporation method. The organic phase composed of PLA and dichloromethane was stirred in aqueous phase including Ca2+ ions to yield oil in water emulsion. During emulsification, stirring rate was increased so as to produce the W/O/W emulsion that results in microspheres with internal pores. The interface of internal water/oil was stable in W/O/W emulsion, which was explained that the bond between Ca2+ ions and carboxyl group of poly(lactic acid) would be stabilized the internal water/oil interface. Adding PO4 3- aqueous solution prompted to precipitate low crystallized hydroxyapatite on the external oil/water interface, and the precipitated hydroxyapatite would stabilizied microspheres formation. The resulting microspheres were approximately 100-500 µm with internal spherical pores of 10-200 µm in diameter. The porous biodegradable microspheres were expected to be utilized as injectable bone substitutes that allow bone ingrowth and bone regeneration.



Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.






F. Nagata et al., "Preparation of Porous Poly(Lactic Acid)/Hydroxyapatite Microspheres Intended for Injectable Bone Substitutes ", Key Engineering Materials, Vols. 284-286, pp. 819-822, 2005

Online since:

April 2005




[1] O. Gauthier, I. Khairoun, J. Bosco, I. Obadia, X. Bourges, C. Rau, D. Magne, J.M. Bouler, E. Aguado, G. Daculsi and P. Weiss: J. Biomed. Mater. Res., 66A (2003), pp.47-54.

DOI: 10.1002/jbm.a.10506

[2] F. Nagata, T. Miyajima and Y. Yokogawa: Chem. Lett., 32, 9 (2003), pp.784-785.

[3] L.L. Hench: J. Am. Ceram. Soc. 81, 7 (1998), pp.1708-1728.

[4] R.A. Ayers, S.J. Simske, C.R. Nunes and L.M. Wolford: J. Oral Maxillofac. Surg., 56, 11 (1998), pp.1297-1301.

[5] R.W. Bucholz, A. Carlton and R. Holmes: Clin. Orthop., 240, (1989), pp.53-62 Fig. 3 FT-IR spectra of (a) the resulting PLA/HAp microspheres and (b) PLA as received.

In order to see related information, you need to Login.