In Vitro and In Vivo Characterization of Various Ferrites for Hyperthermia in Cancer-Treatment
Ceramic ferrites can be used to cancer-treatment. Heating of certain organs or tissue up to temperature between 42oC and 45oC preferentially for cancer therapy is called hyperthermia. We synthesized ferrites with various compositions in the system Co1-xNixFe2O4 as hyperthermic thermoseed in cancer-treatment and evaluated their effects on the necrosis of cancer cells under alternating magnetic field in vivo as well as in vitro. When a CoFe2O4 was placed into 0.2 ml distilled water, the greatest temperature change in this study, Δ T=29.3oC, was observed. More than half of the carcinoma cells were dead after exposure to alternating magnetic field using CoFe2O4, while normal cells were survived more than 60%. The injection of this ferrite particles into the tumor bearing mice was able to suppress the number and volume of tumors. CoFe2O4 is expected the useful hyperthermic thermoseed in cancer-treatment because it exhibited the greatest necrosis of carcinoma cells in vitro and in vivo.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
D.H. Kim et al., "In Vitro and In Vivo Characterization of Various Ferrites for Hyperthermia in Cancer-Treatment ", Key Engineering Materials, Vols. 284-286, pp. 827-830, 2005