Assessment of the Potential of Bonelike® Graft for Bone Regeneration by Using an Animal Model


Article Preview

BonelikeÒ graft that mimics the inorganic composition of bone tissue has been developed and characterized over the last decade. To evaluate the osteoconductivity of BonelikeÒ two granule size ranges, one ranging from 150-250µm and the other from 250-500µm were implanted in the femurs of New Zealand White rabbits, aiming at being clinically used in different medical applications, such as dentistry and orthopaedics. In order to facilitate the medical application of the BonelikeÒ graft the use of a commercially available polymeric vehicle was also analyzed. Radiological examination, histological studies and scanning electron microscopy (SEM) analyses revealed that the surface of Bonelike® granules was almost completely surrounded by new bone formation after 12 weeks of implantation, which proves its highly osteoconductive behaviour.



Key Engineering Materials (Volumes 284-286)

Main Theme:

Edited by:

Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.




J.V. Lobato et al., "Assessment of the Potential of Bonelike® Graft for Bone Regeneration by Using an Animal Model ", Key Engineering Materials, Vols. 284-286, pp. 877-880, 2005

Online since:

April 2005




[1] J.D. Santos, G.W. Hastings, J.C. Knowles, European Patent WO 0068164.

[2] M.A. Lopes, J.D. Santos, F.J. Monteiro, et. al J. Biomed Mater Res, 54, 2001, 463-469.

[3] M.A. Lopes, J.D. Santos, J. Biomed Mater Res, 48, 1999, 734-740.

[4] M.A. Lopes, F.J. Monteiro, J.D. Santos, Biomaterials, 2, 1999, 2085-2090. a b.

Fetching data from Crossref.
This may take some time to load.