In Vivo Behavior of Calcium Phosphate Glasses with Controlled Solubility
Resorbable calcium phosphate glasses offer interesting solutions in the biomedical field, as bone cavity fillers, drug delivery systems, biodegradable reinforcing phase in the case of composites for bone fixation devices and tissue engineering scaffolds. In this work, two different glass formulations in the systems 44.5CaO-44.5P2O5-(11-X)Na2O-XTiO2 (X=0or 5) have been elaborated. It is known that the incorporation or TiO2 into the vitreous system reduces considerably the solubility of the glasses. To study the material solubility effect on the in vivo response, glass particles of the two formulations were implanted in rabbits. Results showed that both glasses elicited a similar biological response and good biocompatibility. The percentage of new bone formation in the glasses was comparable to that obtained for the autologous bone (control) after 12 weeks of implantation. The materials showed to have an osteoconductive potential. Finally, this study showed that in spite of the solubility difference of the studied glasses, there were no significant differences in the in vivo response.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
M. Navarro et al., "In Vivo Behavior of Calcium Phosphate Glasses with Controlled Solubility", Key Engineering Materials, Vols. 284-286, pp. 893-896, 2005