The Drug Delivery Application of Sponge Phased Silica Ceramic Structure
This work describes an innovative approach to preparation of the highly controlled drug delivery materials that involves a self-assembly process at the molecular level based upon the silicified L3 phase silicates and thermoresponsive PNIPAm integrated L3 phase silicates. The materials designed by the integration of thermosensitive polymer have been prepared and demonstrated for the highly controlled drug releasing system over a longer period of time due to their high degree of continuity and contigunity in 3-D interconnected porous structure. This approach is suitable for long term drug delivery systems with constant release in hard tissue engineering due to nanodiffusion mechanism. The structural characterization was achieved by TEM, SEM, SAXD, solid-state 29Si NMR, and BET.
Hai-Doo Kim, Hua-Tay Lin and Michael J. Hoffmann
J. H. Chang et al., "The Drug Delivery Application of Sponge Phased Silica Ceramic Structure", Key Engineering Materials, Vol. 287, pp. 39-43, 2005