Construction of Biodegradable Multilayer Films via Layer-by-Layer Self-Assembly as Gene Delivery System

Abstract:

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Films composed of alternating layers of protamine and DNA were constructed using the layer-by-layer method on quartz and subsequently studied the enzymic degradation in vitro. UV-visible spectrometry measurement indicated the uniform assembly of Protamine/DNA multilayer films. UV-visible spectrometry and fluorescence spectrometry results revealed that the Protamine/DNA multilayer films were in vitro enzymic biodegradable. The novel biodegradable multilayer of Protamine/DNA may have great potential for gene therapy applications in tissue engineering, medical implant etc.

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

101-104

DOI:

10.4028/www.scientific.net/KEM.288-289.101

Citation:

K. F. Ren et al., "Construction of Biodegradable Multilayer Films via Layer-by-Layer Self-Assembly as Gene Delivery System", Key Engineering Materials, Vols. 288-289, pp. 101-104, 2005

Online since:

June 2005

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Price:

$35.00

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