An Implantable Immunosuppressive Cyclosporine Drug Delivery System

Abstract:

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In the article a kind biodegradable drug carrier (glycolide-co-lactide-co-caprolactone) tricomponent copolymer (PGLC) was synthesized by ring opening copolymerization of glycolide (GA), lactide (LA) and ε-caprolactone (CL), and was used to manufacture an implantable drug preparation---Cyclosporine-PGLC drug delivery system (Cs-PGLC DDS).The Cs could slowly release from the Cs-PGLC DDS near linearly and last for a long time in vitro. A clinically significant Cs concentration in the cornea and anterior chamber could be achieved by implanting the Cs-PGLC DDS in anterior chamber. It was demonstrated that the Cs-PGLC DDS is a long-effective intraocular immunosuppressive agent for remaining corneal allograft clear and significantly prolong its survival time.

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

125-128

DOI:

10.4028/www.scientific.net/KEM.288-289.125

Citation:

S. G. Wang et al., "An Implantable Immunosuppressive Cyclosporine Drug Delivery System", Key Engineering Materials, Vols. 288-289, pp. 125-128, 2005

Online since:

June 2005

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Price:

$35.00

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