Confocal Study of Specific Targeting of Quantum Dot Nanocomposites to Cancer Cells


Article Preview

Targeting of drugs and therapeutic materials to target cells or designated intracellular locations relies upon their cellular / sub-cellular targeting and trafficking. The ideal optical properties of quantum dots offer the possibility of using them as fluorescent probes to study the intracellular uptake and pathway of drugs or biomolecules. Quantum dots, ZnS coated CdSe, were synthesized and successfully incorporated into polystyrene (PS) particles grafted with carboxyl groups and folic acid was attached to the nanoparticle surfaces. The nanocomposites were monodisperse and highly luminescent, and their intracellular uptake to cancer cells was investigated using confocal microscopy.



Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata




Y. Zhang and J. Zhang, "Confocal Study of Specific Targeting of Quantum Dot Nanocomposites to Cancer Cells", Key Engineering Materials, Vols. 288-289, pp. 155-158, 2005

Online since:

June 2005





[1] P.S. Low, A.C. Antony: Adv. Drug Deliv. Rev. Vol 56 (2004), 1055-58.

[2] A.C. Antony: Blood Vol 79 (1992), 2807-20.

[3] J.F. Ross, P.K. Chaudhuri, M. Ratnam: Cancer Vol 73 (1994), 2432-43.

[4] W. Chan, D.J. Maxwell, X.H. Gao, R.E. Bailey, M.Y. Han, S.M. Nie: Current Opinion in Biotechnology Vol 13 (2002), 40-46.

[5] Z.A. Peng, X.G. Peng: J. Am. Chem. Soc. Vol 123 (2001), 183-4.

[6] B.O. Dabbousi, J. Rodriguez-Viejo, F.V. Mikulec, J.R. Heine, H. Mattoussi, R. Ober, K.F. Jensen, M.G. Bawendi: J. Phys. Chem. B Vol 101 (1997), 9463-75.


[7] C.K. Kumar, M.P. Moyer, P.K. Dudeja, H.M. Said: J. Bio. Chem. Vol 272 (1996), 6226- 31. a b c.