Spherical Porous Microparticle of Hydroxyapatite/Polysaccharides Nanocomposites

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Nanocomposites of hydroxyapatite / chondroitin sulfate or hyaluronic acid were prepared by a wet method through a self-organization. In the nanocomposites, the c-axis of hydroxyapatite nanocrystals was oriented along the longitudinal axis of the aggregations. The spherical porous microparticles by using a spray drying method were developed with the size range of 1.0 to 20 µm, specific surface area of c.a. 100 m2g-1 and porosities of over 60vol%. No thermal decomposition of polysaccharides was occurred through the spray drying processes. It is note worth that the zeta-potential of the microparticles were gradually changed to be negative value of -35mV against the content of polysaccharides. The animal experiments implanted under the skin showed that the HAp/ChS had a good biocompatibility for 4 week implantations. The spherical microparticles will be applicable to create more complicated composites and drug carriers.

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Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

159-162

Citation:

T. Ikoma et al., "Spherical Porous Microparticle of Hydroxyapatite/Polysaccharides Nanocomposites", Key Engineering Materials, Vols. 288-289, pp. 159-162, 2005

Online since:

June 2005

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$38.00

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