Spherical Porous Microparticle of Hydroxyapatite/Polysaccharides Nanocomposites
Nanocomposites of hydroxyapatite / chondroitin sulfate or hyaluronic acid were prepared by a wet method through a self-organization. In the nanocomposites, the c-axis of hydroxyapatite nanocrystals was oriented along the longitudinal axis of the aggregations. The spherical porous microparticles by using a spray drying method were developed with the size range of 1.0 to 20 µm, specific surface area of c.a. 100 m2g-1 and porosities of over 60vol%. No thermal decomposition of polysaccharides was occurred through the spray drying processes. It is note worth that the zeta-potential of the microparticles were gradually changed to be negative value of -35mV against the content of polysaccharides. The animal experiments implanted under the skin showed that the HAp/ChS had a good biocompatibility for 4 week implantations. The spherical microparticles will be applicable to create more complicated composites and drug carriers.
Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata
T. Ikoma et al., "Spherical Porous Microparticle of Hydroxyapatite/Polysaccharides Nanocomposites", Key Engineering Materials, Vols. 288-289, pp. 159-162, 2005