PEG-Containing Polymeric Films and Gels as Postoperative Tissue Adhesion Barriers

Abstract:

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This study was designed to evaluate the effect of polyethylene glycol (PEG) and nonsteroidal anti-inflammatory drug (ibuprofen) on the prevention of postoperative tissue adhesion. For this, we synthesized poly(L-lactic acid)-PEG diblock copolymers and used them to prepare ibuprofen-loaded films as tissue adhesion barrier films. We also prepared lower critical solution temperature (LCST)-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and ibuprofen as tissue adhesion barrier gels. The prepared films and gels with/without ibuprofen were evaluated by the observations of peritoneal tissue adhesion via animal study using a rat model.

Info:

Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

373-376

DOI:

10.4028/www.scientific.net/KEM.288-289.373

Citation:

A.K. Go et al., "PEG-Containing Polymeric Films and Gels as Postoperative Tissue Adhesion Barriers", Key Engineering Materials, Vols. 288-289, pp. 373-376, 2005

Online since:

June 2005

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Price:

$35.00

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