Biomimetic Mineralization and Bioactivity of Phosphorylated Chitosan

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Phosphorylated chitosans were synthesized as templates to manipulate hydroxyapatite (HA) crystal nucleation, growth and microstructure. Two kinds of insoluble phosphorylated chitosan were soaked in saturated Ca(OH)2 solution for 4 d and in 1.5× SBF (simulated body fluid) solutions for 14 d at 37 °C for biomimetic mineralization. A lower [P]-content of phosphorylated chitosan promoted greater mineralization than higher [P]-content. Phosphorylated chitosan inhibited osteoblast proliferation and differentiation in vitro, while calcium phosphate phosphorylated chitosan composites did not.

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Periodical:

Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata

Pages:

429-432

Citation:

Z. Q. Chen et al., "Biomimetic Mineralization and Bioactivity of Phosphorylated Chitosan ", Key Engineering Materials, Vols. 288-289, pp. 429-432, 2005

Online since:

June 2005

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$38.00

[1] S Mann. Nature. 332(1988), p.119.

[2] P Calvert, S Mann. Nature. 386(1997), p.127.

[3] S.I. Stupp, and P. V Braun. Science. 277 (1997), p.1242.

[4] Y Yokogawa, K Nishizawa, F Nagata, et al. J Sol-Gel Sci and Tech. 21(2001), p.105.

[5] H.K. Varma, Y.Y. okogawa, F.F. Espinosa. Biomaterials. 209(1999), p.879.

[6] F.L. Granja, M.A. Barbosa, L Pouysegu. J Mater Sci. 36(2001), p.2163.

[7] L S i, Q Liu, de Wiln J, B Zou, et al. J Mater Sci. Mater. Med. 8(1997), p.543.

[8] M.R. Mucalo, Y Yokgawa,. M Toriyama, et al. J Mater. Sci. Mater. Med. 6(1995), p.597.

[9] M. R Mucalo, Y Yokogawa, T Suzuki, et al. J Mater. Sci. Mater. Med. 6(1995), p.658.

[10] O.N. Tretinnikov, K Kato, Y Ikada. J Biomed Mater Res. 28(1994), p.1365.

[11] K Nishi , A Fbina, S Nishimura, et al. J Biol Macromol. 8(1986), p.311.

[12] T Kokubo, H Kushitani, S Sakka, et al. J Biomed Mater Res. 24 (1990), p.721.

[13] H Ohgushi, Y Dohi, T Katudo, et al. J Biomed Mater Res. 32(1996), p.33.

[14] S H Rhee. and J. Tanaka . Biomaterials, 20(1999), p.2155.

[15] G. R Sauer and E Wuthier. J Biol Chem. 263(1988), p.13718.

[16] T Hanawa and M. Ota Biomaterials. 12(1991), p.767.

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