Mechanical Properties and Antithrombogenecity of Blend Membrane of Silk Fibroin


Article Preview

The silk fibroin blend membranes were prepared by adding a small amount of poly (vinyl alcohol) (PVA) and heparin. By controlling the preparation conditions, the tensile strength and elongation at break reached to 8.86 MPa and 231.8%, respectively. Meanwhile the in vitro antithrombogenecity significant increased. The clot times (APTT, TT and PT) all exceeded the measurement limit of clot detection instrument. It is expectable using these natural materials to prepare small caliber vessel.



Key Engineering Materials (Volumes 288-289)

Edited by:

Xingdong Zhang, Junzo Tanaka, Yaoting Yu and Yasuhiko Tabata




Y. Tang et al., "Mechanical Properties and Antithrombogenecity of Blend Membrane of Silk Fibroin", Key Engineering Materials, Vols. 288-289, pp. 445-448, 2005

Online since:

June 2005




[1] Q. Lv, C.B. Cao, H.Z. Zhai and H.S. Zhu. Chinese Science Bulletin, Vol. 49 (2004), p.538.

[2] M.Z. Li, N Minoura and L.X. Dai. Macro. Mater. Eng. Vol. 286 (2001), p.529.

[3] G. Freddi, M. Romano and M.R. Massafra. J. Appl. Polym. Sci. Vol. 56 (1995), p.1537.

[4] Toshihisa Tanaka, Tetsuya Tanigami. Polym. Inter. Vol 45 (1998), p.175.

[5] Zun Chen, Ruifeng Zhang and Makoto Kodama. J. Appl. Polym. Sci. Vol. 76 (2000), p.328.

[6] Q. Lv, C.B. Cao and H.S. Zhu. Jounal of Material Science: Material in Medicine Vol. 15 (2004), p.1.

[7] C.X. Liang, K. Hirabayashi. Polymer, Vol. 33 (1992), p.4388.

[8] K. Hirabayashi, H. Ishikava, Sen-I Gakkaishi, Vol. 23 (1967), p.538.

[9] J. Magoshi, S. Nakamura. J. Appl. Polym. Sci. Vol. 19 (1975), p.1013.

[10] G. Freddi, G. Pessina and M. Tsukada. Inter. J. of Biological Macromolecules, Vol. 24 (1999), p.251.

[11] Oley N. Tretinnikov, Langmuir, Vol. 17 (2001), p.7406. PT(S) APTT(S) TT(S) Plasma 12. 2 36. 7 18. 9 Pure SF 13. 4 37. 8 19. 0 SF/PVA(93/7) 13. 7 38. 4 19. 5 SF/PVA/heparin >50 >150 >200.