Mice macrophages which were mixed with β-tricalcium phosphate (β-TCP) ceramics powder were cultured, both calcium and phosphorus concentrations in the culture medium were evidently higher than that of β-TCP ceramics powder without cells. The microscope and SEM observation showed that macrophages wrapped β-TCP particles, and then phagocytized them into cytoplasm. The pH values inside and outside macrophage in β-TCP-bearing were tested. The histochemistry observation showed that there were many carbonic anhydrase positive grains in the cytochylema of macroghage after β-TCP ceramics powder being implanted. TEM investigation indicated that many β-TCP particles were phagocytized into the cytochylema of macroghage, and then vacuole was found after particles had degraded. The results showed that macrophages could take part in the degradation of calcium phosphate ceramics in two different ways.